Indolent course as presentation in T-prolymphocytic leukaemia
نویسندگان
چکیده
منابع مشابه
T-Cell Prolymphocytic Leukaemia: A Case Series
T-prolymphocytic leukaemia (T-PLL) is a rare mature T-cell lymphoproliferative disorder. It is seen more often in middle-aged and elderly individuals with a median age of onset of 65 years and a male predominance of 2:1. Patients present with hepatosplenomegaly, lymphadenopathy, 15% may have serous effusions and approximately 20% have skin involvement. The white cell count is often above 200 x ...
متن کاملBendamustine is effective in T-cell prolymphocytic leukaemia.
T-cell prolymphocytic leukaemia (T-PLL) is an aggressive T-cell neoplasm with a mature post-thymic T-cell phenotype. Most patients present with markedly elevated leucocyte counts, splenomegaly, lymphadenopathy, hepatomegaly, skin lesions, pleuroperitoneal effusions or central nervous system involvement (Matutes et al, 1991). The most frequent chromosome abnormalities in T-PLL are inv(14)(q11q32...
متن کاملCutaneous involvement as the first manifestation in a case of T-cell prolymphocytic leukaemia.
Mature T-cell malignancies of extracutaneous origin are rare disorders. T-cell prolymphocytic leukaemia (T-PLL) is the most common form of all mature T-cell leukaemias in adults. Secondary skill involvement by T-PLL has been reported in 25% of patients. A case of T-PLL which presented with cutaneous infiltration mimicking a cellulitis-like lesion resistant to antibiotic therapy is described. Th...
متن کاملT-cell Prolymphocytic Leukemia.
BACKGROUND: T-cell prolymphocytic leukemia (T-PLL) is a post-thymic T-cell malignancy with aggressive clinical course. Although T-PLL has been referred to under different designations, it is a distinct clinico-biological entity and should be distinguished from other T-cell disorders. METHODS: The literature on T-PLL is reviewed. Experience on the clinical and laboratory features, differential d...
متن کاملT-cell prolymphocytic leukemia.
T-cell prolymphocytic leukemia is a rare and unusual malignancy characterized by the proliferation of small- to medium-sized prolymphocytes of postthymic origin with distinctive clinical, morphologic, immunophenotypic, and cytogenetic features. Involvement of the peripheral blood, bone marrow, lymph nodes, liver, spleen, and skin can occur. The clinical course is typically very aggressive with ...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1999
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.1999.01485.x